Susan C Baker Selected Research

Papain

12/2017	X-ray Structure and Enzymatic Activity Profile of a Core Papain-like Protease of MERS Coronavirus with utility for structure-based drug design.
5/2015	Murine coronavirus ubiquitin-like domain is important for papain-like protease stability and viral pathogenesis.
2/2014	MERS-CoV papain-like protease has deISGylating and deubiquitinating activities.
7/2013	The papain-like protease of porcine epidemic diarrhea virus negatively regulates type I interferon pathway by acting as a viral deubiquitinase.
1/2012	Coronavirus papain-like proteases negatively regulate antiviral innate immune response through disruption of STING-mediated signaling.
10/2008	A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication.
4/2006	Severe acute respiratory syndrome coronavirus papain-like protease: structure of a viral deubiquitinating enzyme.
12/2004	Identification of severe acute respiratory syndrome coronavirus replicase products and characterization of papain-like protease activity.

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Susan C Baker Research Topics

Disease

21	Infections 10/2022 - 06/2007
11	Severe Acute Respiratory Syndrome 05/2015 - 12/2004
9	Mucocutaneous Lymph Node Syndrome (Kawasaki Disease) 01/2020 - 08/2004
6	Virus Diseases (Viral Diseases) 01/2020 - 05/2010
3	COVID-19 01/2021 - 09/2020
3	Coronavirus Infections 01/2020 - 10/2014
2	Diarrhea 01/2020 - 01/2019
2	Arteritis 09/2017 - 12/2015
2	Bites and Stings (Sting) 07/2013 - 01/2012
2	Aneurysm (Aneurysms) 01/2012 - 08/2004
1	Pneumonia (Pneumonitis) 01/2021
1	Burns 01/2021
1	Neoplasms (Cancer) 09/2020
1	Coronary Aneurysm (Aneurysm, Coronary) 01/2020
1	Acquired Immunodeficiency Syndrome (AIDS) 01/2020
1	Peritonitis 11/2019
1	Cat Diseases (Cat Disease) 11/2019
1	Gastrointestinal Diseases (Functional Gastrointestinal Disorders) 01/2019
1	Pathologic Constriction (Stenosis) 03/2013
1	Inflammation (Inflammations) 01/2012
1	Polyarteritis Nodosa (Periarteritis Nodosa) 01/2012
1	Vasculitis (Vasculitides) 01/2012
1	Melanoma (Melanoma, Malignant) 11/2007

Drug/Important Bio-Agent (IBA)

10	Proteins (Proteins, Gene)FDA Link 01/2021 - 12/2004
10	Peptide Hydrolases (Proteases)FDA Link 12/2017 - 12/2004
9	InterferonsIBA 01/2021 - 05/2010
8	PapainIBA 12/2017 - 12/2004
7	Antiviral Agents (Antivirals)IBA 01/2021 - 06/2007
5	PolyproteinsIBA 01/2018 - 12/2004
4	VaccinesIBA 01/2021 - 04/2008
4	Interferon Type IIBA 01/2020 - 11/2007
3	AntigensIBA 10/2022 - 08/2004
3	Uridylate-Specific EndoribonucleasesIBA 01/2020 - 01/2019
3	Deubiquitinating EnzymesIBA 01/2020 - 06/2007
3	RNA (Ribonucleic Acid)IBA 04/2011 - 02/2008
2	masitinibIBA 01/2021 - 09/2020
2	Pharmaceutical PreparationsIBA 09/2020 - 06/2007
2	Virulence Factors (Pathogenicity Factors)IBA 01/2020 - 01/2019
2	UbiquitinIBA 12/2017 - 06/2007
2	Biomarkers (Surrogate Marker)IBA 12/2014 - 06/2014
2	Protease Inhibitors (Protease Inhibitor)IBA 10/2014 - 10/2014
2	Interferon Regulatory Factor-3 (Interferon Regulatory Factor 3)IBA 07/2013 - 11/2007
2	Phenobarbital (Luminal)FDA Link 03/2013 - 01/2012
2	Immunoglobulin A (IgA)IBA 04/2011 - 12/2005
2	Chymases (Chymase)IBA 04/2006 - 11/2005
1	16S Ribosomal RNAIBA 01/2021
1	Janus KinasesIBA 01/2021
1	Tyrosine Kinase InhibitorsIBA 09/2020
1	SARS-CoV-2 3C-like proteinaseIBA 09/2020
1	EndoribonucleasesIBA 01/2020
1	Peptides (Polypeptides)IBA 01/2020
1	AntibodiesIBA 01/2020
1	Immunoglobulin G (IgG)IBA 01/2020
1	EpitopesIBA 01/2020
1	Neutralizing AntibodiesIBA 01/2020
1	Interferon LambdaIBA 01/2019
1	Attenuated VaccinesIBA 01/2019
1	EnzymesIBA 01/2018
1	2-5A-dependent ribonuclease (RNase L)IBA 01/2017
1	Immunoglobulins (Immunoglobulin)IBA 12/2015
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 12/2015
1	CytokinesIBA 12/2014
1	MicroRNAs (MicroRNA)IBA 12/2014
1	Interferon-betaIBA 10/2014
1	PeriostinIBA 06/2014
1	Multifunctional EnzymesIBA 02/2014
1	PolyubiquitinIBA 07/2013
1	Ubiquitinated ProteinsIBA 07/2013
1	Matrix Metalloproteinase 7 (Matrilysin)IBA 03/2013
1	IntegrinsIBA 03/2013
1	furanIBA 01/2013
1	DipeptidesIBA 01/2013
1	N- ((1R)- 2- (tertbutylamino)- 2- oxo- 1- (3- pyridyl)ethyl)- N- (4- tertbutylphenyl)furan- 2- carboxamideIBA 01/2013
1	Viral Replicase Complex ProteinsIBA 01/2012
1	Coronavirus Papain-Like ProteasesIBA 01/2012
1	Viral RNAIBA 10/2010
1	Indicators and Reagents (Reagents)IBA 03/2009
1	Nucleic AcidsIBA 03/2009
1	Messenger RNA (mRNA)IBA 05/2008
1	Protein Phosphatase 1IBA 05/2008
1	Peptide Initiation Factors (Initiation Factor)IBA 05/2008
1	Transcription Factors (Transcription Factor)IBA 11/2007
1	Toll-Like Receptor 3IBA 11/2007
1	Double-Stranded RNA (RNA, Double Stranded)IBA 11/2007
1	Tretinoin (Retinoic Acid)FDA LinkGeneric 11/2007
1	Cysteine Proteases (Cysteine Protease)IBA 04/2006
1	PeptidomimeticsIBA 11/2005
1	Biological ProductsIBA 11/2005
1	Viral ProteasesIBA 12/2004

Therapy/Procedure

1	Immunotherapy 09/2017
1	Immunomodulation 12/2015
1	Therapeutics 10/2014